Research and Development

Scientific innovation lies at the core of Allergan’s continued success. With a rich and promising pipeline of novel therapies with the potential to advance treatment paradigms, we continue to invest vigorously in our Research and Development (R&D) programs. In fact, we rank in the top quartile of our peer group companies for our R&D investment as a percentage of sales in both the pharmaceutical and medical device industries.(1) In 2007, we invested $646 million into R&D and have doubled our R&D spend over the last four years.(2) With this in mind, we anticipate a number of major approvals this year and beyond to drive both mid- and long-term growth.

Pipeline

Product
Indication
Industry Partners Status
Ophthalmology
Lumigan® (Japan)
Glaucoma (IOP) Senju Review
Lumigan® X
Glaucoma (IOP) Review
ACULAR® X
Inflammation Phase 3
Posurdex®
Retinal Vein Occlusion Phase 3
Posurdex®
Diabetic Macular Edema Phase 3
TRIVARIS™ (Triamcinolone)
Diabetic Retinopathy Phase 3
TRIVARIS™ (Triamcinolone)
Retinal Vein Occlusion Phase 3
ZYMAR® X
Anti-infection Phase 3
Androgen Tear
Dry Eye Phase 2
AGN-745 (Sirna)
Age-Related Macular Degeneration Sirna Therapeutics Phase 2
IOP Lowering
Glaucoma Phase 1
Tyrosine Kinase Inhibitors
Age-Related Macular Degeneration Pre-clinical
Neurosciences
Botox®
Chronic Migraine Phase 3
Alpha Agonists
Neuropathic Pain ACADIA Pharmaceuticals Phase 2
Medical Aesthetics
Botox® (Japan)
Glabellar Lines GlaxoSmithKline Review
Silicone Breast Implants —
Style 410 Cohesive Gel
Breast Reconstruction & Augmentation U.S. Review
Hyaluronic Acid + Lidocaine (U.S.)
Facial Aesthetics Feasibility
JUVÉDERM VOLUMA™ (U.S.)
Facial Aesthetics Feasibility
Obesity Intervention
LAP-BAND®
Adolescent Obesity Clinical
BIB™ (U.S.)
Obesity Feasibility
EASYBAND™ (U.S.)
Obesity Feasibility
Urologics
Botox®
Overactive Bladder (Neurogenic) Phase 3
Botox®
Overactive Bladder (Idiopathic) Phase 2
Botox®
Benign Prostatic Hyperplasia Phase 2
(1)  Internal analysis of public filings of Allergan peer group.
(2)  Adjusted for non-GAAP items. See reconciliation.